Table II.
Genotype and allele frequencies of p73 and MDM2 among cases and controls, and their association with the risk of developing non-small cell lung cancer.
| Genotype | Cases, n (%) (n=186) | Controls, n (%) (n=196) | P-value | OR (95% CI)a |
|---|---|---|---|---|
| p73 G4C14-A4T14 | ||||
| GC/GC | 94 (50.54) | 98 (50.00) | – | 1.00 (Reference) |
| GC/AT | 80 (43.01) | 71 (36.22) | 0.46 | 1.18 (0.77–1.80) |
| AT/AT | 12 (6.45) | 27 (13.78) | 0.04 | 0.46 (0.22–0.97)b |
| AT allele frequency | 104 (27.96) | 125 (31.89) | – | 1.00 (Reference) |
| GC allele frequency | 268 (72.04) | 267 (68.11) | 0.24 | 1.21 (0.88–1.65) |
| MDM2 309 T/G | ||||
| GG | 58 (31.18) | 44 (22.45) | – | 1.00 (Reference) |
| TG | 96 (51.61) | 101 (51.53) | 0.18 | 0.72 (0.45–1.17) |
| TT | 32 (17.21) | 51 (26.02) | 0.01 | 0.48 (0.26–0.86)b |
| G allele frequency | 212 (56.99) | 189 (48.21) | – | 1.00 (Reference) |
| T allele frequency | 160 (23.01) | 203 (51.79) | 0.02 | 0.70 (53–0.94)b |
a
ORs were adjusted for age, sex, cigarette smoking and alcohol consumption.
b
P<0.05. OR, odds ratio; CI, confidence interval; MDM2, murine double minute 2.