Table III.
Risk of lung cancer in association with MDM2 SNP309 and p73 G4C14-to-A4T14 polymorphism.
| p73 genotype | MDM2 genotype | Cases, n (%) (n=186) | Control, n (%) (n=196) | P-value | OR (95% CI)a |
|---|---|---|---|---|---|
| GC/AT + GC/GC | GG + TG | 144 (77.42) | 132 (67.35) | – | 1.00 (Reference) |
| GC/AT + GC/GC | TT | 30 (16.13) | 37 (18.88) | 0.28 | 0.74 (0.44–1.27) |
| AT/AT | GG + TG | 10 (5.38) | 13 (6.63) | 0.42 | 0.71 (0.30–1.66) |
| AT/AT | TT | 2 (1.07) | 14 (7.14) | <0.01 | 0.13 (0.03–0.59)b |
a
ORs were adjusted for age, sex, cigarette smoking and alcohol consumption.
b
P<0.05. OR, odds ratio; CI, confidence interval; MDM2, murine double minute 2.