Figure 1.

(A) Case 1 family tree and the cancer histology of the proband. The arrow indicates the patient. Numbers indicate age (in years) at present, at diagnosis with the cancer type stated or at mortality. (B) Hematoxylin and eosin staining of gastric tissue. Magnification, ×200. Signet ring cell carcinoma arising in this stomach is limited to the lamina propria. The neoplastic cells are easily recognizable because of their typical features consisting of a mucin-replete cytoplasm pushing the nucleus to the periphery of the cell. CDH1+, mutation currier subject; WT, wild-type; HD, Hodgkin's disease.