Table III.

Altered pathways with a percentage change >80%.

Altered pathway	Amount	Percent (%)
Kinesins	39	92.86
Polo-like kinase mediated events	39	92.86
Chromosome maintenance	38	90.48
Meiotic recombination	38	90.48
Deposition of new CENPA-containing nucleosomes at the centromere	38	90.48
Nucleosome assembly	38	90.48
G2/M DNA replication checkpoint	38	90.48
Telomere maintenance	37	88.10
Golgi cisternae pericentriolar stack reorganization	37	88.10
Nuclear factor-kB activation through Fas-associated death domain and receptor interacting protein 1 pathway mediated by caspase-8 and −10	37	88.10
Phosphorylation of proteins involved in G1/S transition by active Cyclin E/Cdk2 complexes	37	88.10
Meiosis	36	85.71
RNA polymerase I promoter clearance	36	85.71
Amyloids	36	85.71
Packaging of telomere ends	36	85.71
RNA polymerase I promoter opening	36	85.71
Cyclin A/B1 associated events during G2/M transition	36	85.71
Leading strand synthesis	36	85.71
Polymerase switching	36	85.71
Polymerase switching on the C-strand of the telomere	36	85.71
Phosphorylation of emi1	36	85.71
Meiotic synapsis	35	83.33
RNA polymerase I chain elongation	35	83.33
G2/M checkpoints	35	83.33
Activation of ATR in response to replication stress	35	83.33
DNA strand elongation	35	83.33
Activation of the pre-replicative complex	35	83.33
Extension of telomeres	35	83.33
Telomere C-strand (lagging strand) synthesis	35	83.33
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	35	83.33
Zinc transporters	35	83.33
Repair synthesis for gap-filling by DNA polymerase in TC-NER	35	83.33
E2F-enabled inhibition of pre-replication complex formation	35	83.33
ER quality control compartment	35	83.33
Cyclin B2 mediated events	35	83.33
Synthesis of DNA	34	80.95
RNA polymerase I transcription	34	80.95
Activation of APC/C and APC/CCdc20 mediated degradation of mitotic proteins	34	80.95
DNA damage bypass	34	80.95
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	34	80.95
E2F mediated regulation of DNA replication	34	80.95
G0 and early G1	34	80.95
Synthesis and interconversion of nucleotide di- and triphosphates	34	80.95
G1/S-specific transcription	34	80.95
Phosphorylation of the APC/C	34	80.95
Removal of the flap intermediate	34	80.95
Chk1/Chk2(Cds1) mediated inactivation of cyclin B/Cdk1 complex	34	80.95