Table I.
Abnormal expression and target genes of miR-139-5p in different types of cancers.
| Cancer type | miR-139-5p expression | Target gene | (Refs.) |
|---|---|---|---|
| Head and neck/oral cancer | Downregulated | Unknown | (6,7) |
| Breast cancer | Downregulated | TOP2a, H2AFV, HRAS, RAF, NFKB1, PIK3CA, RHOT1 | (20,35,69) |
| Gastric cancer | Downregulated | CXCR4, c-Jun | (79) |
| Endometrial serous adenocarcinoma | Downregulated | Unknown | (16) |
| Colorectal cancer | Downregulated | IGF-1R, ROCK2, RAP1B, TSPAN5, FOXO1A, TNFα, Fas, AMFR, NOTCH1, ETS1 | (38,48,50,52,53,56) |
| Bladder cancer | Downregulated | Unknown | (18) |
| Hepatocellular carcinoma | Downregulated | EZH2, ROCK2, ZEB1/2, c-Fos | (57–59,63–65) |
| Ovarian cancer | Downregulated | TOP2a, RACGAP1, DNAH9, E2F3 | (20) |
| Esophageal squamous cell carcinoma | Downregulated | NR5A2 | (21,22) |
| Thyroid carcinoma | Downregulated | Unknown | (23) |
| Glioblastoma | Downregulated | Mcl-1 | (24) |
| Basal cell carcinoma | Downregulated | Unknown | (25) |
| Renal cell carcinoma | Downregulated | Unknown | (26) |
| Lung squamous cell carcinoma | Downregulated | CXCR4 | (27) |
| Non-small cell lung cancer | Downregulated | IGF-1R | (28) |
| Pancreatic cancer | Upregulated | Unknown | (29) |
| Granulosa cell tumor | Upregulated | PGRMC1 | (32) |
miR, microRNA.