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. 2017 Jun 8;14(2):1648–1656. doi: 10.3892/ol.2017.6355

Figure 2.

Figure 2.

Effects of ZOL-loaded HA/bone cement on cell growth. The inhibitory effects of ZOL-loaded HA/bone cement were determined by MTT assay. ZOL-loaded HA/bone cement inhibited the growth of tumor cells. Although ZOL-loaded Primafix® demonstrated inhibitory effects in these tumor cells, the growth inhibitory effects were weak and short-acting compared with the other materials. There were no significant differences in effects on cell growth observed between the two types of ZOL-loaded bone cement, Simplex P® and Cemex RX®, the polymerization temperatures of which reached 70–110°C, and 40–55°C, respectively. The growth inhibitory effects of these materials gradually decreased over 14 days, and strong inhibitory effects were observed in LM8 cells in particular. HA, hydroxyapatite; ZOL, zoledronic acid.