Table II.
Comparison of the patient background between the DPD-high and DPD-low expression groups.
| Characteristic | Patients exhibiting high DPD expression (n=18) | Patients exhibiting low DPD expression (n=48) | P-value |
|---|---|---|---|
| Median age, years (range) | 71.5 (56–79) | 68.5 (46–81) | 0.527 |
| Sex | 0.001 | ||
| Male | 16 (88.9%) | 20 (41.7%) | |
| Female | 2 (11.1%) | 28 (58.3%) | |
| Surgical procedure | 0.686 | ||
| PD | 12 (66.7%) | 28 (58.3%) | |
| DP | 5 (27.8%) | 14 (29.2%) | |
| TP | 1 (5.6%) | 6 (12.5%) | |
| Median size of tumor, mm (range) | 33.5 (15–90) | 38 (15–105) | 0.319 |
| Pathological type | 0.323 | ||
| tub1 | 9 (50.0%) | 30 (62.5%) | |
| tub2 | 7 (38.9%) | 11 (22.9%) | |
| por | 2 (11.1%) | 3 (6.3%) | |
| Others | 0 (0.0%) | 4 (8.3%) | |
| Pathological T factor | 0.727 | ||
| T3 | 18 (100.0%) | 47 (97.9%) | |
| T4 | 0 (0.0%) | 1 (2.1%) | |
| Pathological N factor | 0.038 | ||
| N0 | 8 (44.4%) | 9 (18.8%) | |
| N1 | 10 (55.6%) | 39 (81.3%) | |
| Stage (7th UICC classification) | 0.101 | ||
| IIA | 8 (44.4%) | 9 (18.8%) | |
| IIB | 10 (55.6%) | 38 (79.2%) | |
| III | 0 (0.0%) | 1 (2.1%) |
DPD, dihydropyrimidine dehydrogenase; PD, pancreaticoduodenectomy; DP, distal pancreatectomy; TP, total pancreatectomy; tub1, well-differentiated tubular adenocarcinoma; tub2, moderately differentiated tubular adenocarcinoma; por, poorly differentiated adenocarcinoma; T, tumor; N, node; UICC, Union for International Cancer Control.