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. 2017 Jun 8;14(2):1536–1542. doi: 10.3892/ol.2017.6350

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Copyright: © Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Representative immunohistochemical staining of CMTM5 protein in tissue microarray. (A) Positive immunostaining of CMTM5 protein was mainly localized in the membrane and cytoplasm of renal epithelial cells in adjacent non-cancerous kidney tissues (magnification, ×200). The representative areas with positive immunostaining are indicated by arrows. (B) CMTM5 protein was either absent or weakly expressed in RCC tissues (magnification, ×200). (C) Percentage of CMTM5 immunostaining in RCC and normal adjacent renal tissues. (D) Relative expression of CMTM5 mRNA in metastatic renal cell adenocarcinoma cell lines ACHN and CAKII and metastatic clear renal cell adenocarcinoma cell line OS-RC-2, as well as the human kidney HK2 cell line. CMTM5, CKLF-like MARVEL transmembrane domain-containing 5; RCC, renal cell carcinoma.