Table 1.
Demographic, intermediate marker and risk information on higher and lower risk participants seen in person compared with those that were not seen
| Higher risk seen | Higher risk not seen | p Value | Lower risk seen | Lower risk not seen | p Value | ||
|---|---|---|---|---|---|---|---|
| n | 74 | 75 | 111 | 770 | |||
| Age (95% CI) | 72.2 (69.0 to 75.5) | 70.8 (68.1 to 74.0) | 0.252 | 64.9 (62.8 to 66.6) | 67.1 (64.9 to 70.6) | <0.001 | |
| Male gender (%) | 63 (85.1) | 54 (72.0) | 0.072 | 31 (27.9) | 243 (31.6) | 0.511 | |
| First-degree relative (%) | 36 (48.6) | 22 (29.3) | 0.019 | 9 (8.1) | 107 (13.9) | 0.100 | |
| Current smoker (%) | 1 (1.4) | 0 (0) | 0.497 | 11 (9.9) | 17 (2.2) | <0.001 | |
| Past smoker (%) | 38 (51.4) | 31 (41.3) | 0.252 | 51 (45.9) | 293 (38.1) | 0.119 | |
| Diabetes mellitus (%) | 8 (10.8) | 4 (5.3) | 0.245 | 8 (7.2) | 33 (4.3) | 0.222 | |
| High cholesterol (%) | 33 (44.6) | 31 (41.3) | 0.742 | 35 (31.5) | 213 (27.7) | 0.430 | |
| Ischaemic Heart disease (%) | 13 (17.6) | 11 (14.7) | 0.662 | 3 (2.7) | 31 (4) | 0.791 | |
| Hypertension (%) | 34 (45.9) | 27 (36) | 0.246 | 40 (36) | 228 (29.6) | 0.186 | |
| Drink coffee (%) | 65 (87.8) | 71 (94.7) | 0.159 | 108 (97.3) | 694 (90.1) | 0.012 | |
| Drink alcohol (%) | 67 (90.5) | 66 (88) | 0.792 | 101 (91) | 674 (87.5) | 0.351 | |
| Constipation (%) | 22 (29.7) | 29 (38.7) | 0.301 | 17 (15.3) | 113 (14.7) | 0.776 | |
| Anxiety/depression (%) | 14 (18.9) | 15 (20) | 0.999 | 13 (11.7) | 87 (11.3) | 0.873 | |
| Head injury (%) | 36 (48.6) | 36 (48) | 0.999 | 26 (23.4) | 218 (28.3) | 0.309 | |
| Hyposmia ≤27/40 on UPSIT (109 available) | 13 of 56 (23.2%) | 16 of 53 (30.2%) | 0.666 | (653 available) | 8 of 88 (9.1%) | 76 of 565 (13.3%) | 0.307 |
| Subjective RBD ≥5 on RBDSQ (147 available) | 18 of 75 (24.0%) | 10 of 72 (13.8%) | 0.141 | (880 available) | 14 of 112 (12.5%) | 81 of 768 (10.5%) | 0.513 |
| Slow finger tapping KS ≤44 taps in 30 s (124 available) | 21 of 67 (31.3%) | 12 of 57 (21.1%) | 0.161 | (749 available) | 12 of 92 (13.0%) | 100 of 657 (15.2%) | 0.754 |
| Risk estimate year 1 (IQR) | 9.9 (6.9–15.1) | 15.3 (12.3–18.2) | <0.001 | 136.8 (54.3–207.3) | 78.1 (48.2–118.7) | <0.001 | |
| Rank year 1 (IQR) | 54 (25–100) | 103 (71–133) | <0.001 | 860 (424–1001) | 580 (373–784) | <0.001 |
Information from survey answers in year 1. Hypertension defined according to self-report or use of diuretics, ACE inhibitors and angiotensin receptor blocking drugs, calcium channel blockers, and beta blockers (including propranolol, atenolol, bisoprolol, but not sotalol or timolol). High cholesterol defined according to self-report or statin use. Diabetes mellitus defined according to self-report or use of metformin, gliclazide or insulin.
UPSIT, University of Pennsylvania Smell Identification Test; RBDSQ, RBD screening questionnaire; KS, kinesia score.