Figure 7.
Hepatocyte myeloid differentiation primary-response gene 88 (Myd88) deletion changes gut microbiota composition. (A) PCoA based on the unweighted UniFrac analysis on operational taxonomic units (OTUs) (n=12). Each symbol representing a single sample is coloured according to the group. (B) Composition of abundant bacterial phyla identified in the gut microbiota (n=12). (C–J) Relative abundances (percentage of 16S rRNA sequences) of the various bacterial genera in each sample among each group of mice. Data are presented as mean±SEM (n=9–10). Data with different superscript letters are significantly different (p<0.05) according to post hoc one-way analysis of variance. See also online supplementary tables S2 and S3. CT, control diet; HFD, high-fat diet; LKO, liver-specific knockout mice; WT, wild type.