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. 2016 Mar 18;66(4):633–643. doi: 10.1136/gutjnl-2015-309595

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This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Hierarchical Ward-linkage clustering of biopsy samples based on the Pearson correlation of the abundance of bacterial co-occurrence clusters in each sample (59 individuals with colorectal cancer (CRC) and 56 healthy controls). Four distinct groups of samples were defined. Sample Group 1 and Sample Group 2 only comprises individuals with cancer and display high abundances of the Pathogen Cluster and the Prevotella Cluster, respectively. Sample Group 3 contains mostly samples from healthy controls, which have a high relative abundance of Firmicutes Cluster 1. Sample Group 4 comprises 60% individuals with cancer with high relative abundances of Bacteroidetes Clusters 1 and 2. Firmicutes Cluster 2 was found to be most abundant in individuals with CRC from Sample Groups 3 and 4. Column annotation: cancer biopsy (blue) and control biopsy (red).