Table 1.
Association of IL-17 lymphocyte count and clinicopathological features in CRC (n=1148)
| Clinicopathological features | IL-17* lymphocyte count |
p Value | |
|---|---|---|---|
| Median/mean | Min–max | ||
| All | 3/13.8 | 0–350 | |
| Tumour location | |||
| Right-sided | 3/12.6 | 0–200 | 0.94† |
| Left-sided | 3/14.3 | 0–332 | 0.13‡ |
| Rectum | 4/13.7 | 0–350 | |
| MMR status | |||
| Proficient | 3/13.6 | 0–350 | 0.18 |
| Deficient | 4/14.5 | 0–167 | |
| pT stage | |||
| pT1–2 | 5.5/15.1 | 0–150 | 0.03 |
| pT3–4 | 3/13.7 | 0–350 | |
| pN stage | |||
| pN0 | 4/15.5 | 0–350 | 0.03 |
| pN1–2 | 3/12.3 | 0–350 | |
| Tumour grade | |||
| G1–2 | 4/14.2 | 0–350 | 0.01 |
| G3 | 2/12.1 | 0–200 | |
| Vascular invasion | |||
| Absent | 4/15.1 | 0–350 | 0.03 |
| Present | 3/10.7 | 0–250 | |
| Tumour border | |||
| Pushing | 4/12.3 | 0–250 | 0.78 |
| Infiltrating | 3/14.9 | 0–350 | |
| Peritumoral lymphocytic inflammation | |||
| Absent | 3/13.4 | 0–350 | <0.001 |
| Present | 7.5/15.8 | 0–250 | |
| Local recurrence | |||
| Absent | 1/8.5 | 0–350 | 0.35 |
| Present | 1/6.1 | 0–200 | |
| Distant metastasis | |||
| Absent | 1/8.2 | 0–350 | 0.10 |
| Present | 1/3.8 | 0–30 | |
| Death | |||
| Censured | 3/14.1 | 0–350 | 0.5 |
| Present | 4/13.8 | 0–332 | |
p Value calculated according to the Mann–Whitney test. Significant p values are shown in bold.
*As assessed by staining I (see ‘Materials and methods’).
†Right-sided versus left-sided.
‡Right-sided or left-sided versus rectum.
CRC, colorectal cancers; IL, interleukin; MMR, mismatch repair.