Table II.
Independent prognostic factors for overall survival in patients with hepatitis B virus-associated advanced hepatocellular carcinoma according to univariate and multivariate analysis.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age | 0.983 | 0.971–0.996 | 0.009 | |||
| Leukocytes, ×109 cells/l | 1.085 | 1.042–1.130 | 0.000 | |||
| Neutrophils, ×109 cells/l | 1.130 | 1.077–1.186 | 0.000 | 1.104 | 1.046–1.165 | 0.000 |
| AMC, ×109 cells/l | 1.348 | 1.013–1.794 | 0.040 | |||
| ALC, ×109 cells/l | 0.832 | 0.613–1.129 | 0.237 | |||
| LMR | 0.765 | 0.675–0.867 | 0.000 | 0.858 | 0.754–0.976 | 0.020 |
| Platelets, ×109 cells/l | 1.002 | 1.001–1.004 | 0.006 | |||
| AST, U/l | 1.001 | 1.000–1.001 | 0.000 | |||
| AFP, ng/dl, >400 vs. ≤400 | 2.30 | 1.649–2.309 | 0.000 | 1.739 | 1.221–2.478 | 0.002 |
| Ascites, yes vs. no | 2.05 | 1.444–2.909 | 0.000 | |||
| Tumor number, <3 vs. ≥3 | 1.306 | 1.106–1.542 | 0.002 | |||
| Tumor size, cm, <1 vs. ≥1 | 3.450 | 1.682–7.077 | 0.001 | |||
| PVTT, yes vs. no | 2.661 | 1.792–3.951 | 0.000 | 1.984 | 1.296–3.037 | 0.002 |
HR, hazard ratio; CI, confidence interval; ALC, absolute lymphocyte count; AMC, absolute monocyte count; LMR, lymphocyte-to-monocyte ratio; AST, aspartate transaminase; ALP, alkaline phosphatase; AFP, α-fetoprotein; PVTT, portal vein tumor thrombus.