Table 1.
Relationship of serum DKK1 autoantibodies with clinicopathological characteristics of 206 NSCLC patients
| Group | N (%) | Pep A
|
P-value | Pep B
|
P-value | Pep C
|
P-value | Pep D
|
P-value |
|---|---|---|---|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||||||
| Age, years | 0.267 | 0.064 | 0.142 | 0.715 | |||||
| >60 | 92 (45) | 0.49 (0.35–0.74) | 0.55 (0.43–0.94) | 0.52 (0.36–0.72) | 0.52 (0.39–0.92) | ||||
| ≤60 | 114 (55) | 0.45 (0.32–0.67) | 0.51 (0.35–0.78) | 0.46 (0.31–0.64) | 0.54 (0.38–0.84) | ||||
| Gender | 0.038 | 0.034 | 0.003 | 0.105 | |||||
| Male | 144 (70) | 0.50 (0.33–0.78) | 0.57 (0.40–0.89) | 0.52 (0.35–0.79) | 0.56 (0.40–0.90) | ||||
| Female | 62 (30) | 0.45 (0.28–0.59) | 0.51 (0.35–0.69) | 0.41 (0.29–0.57) | 0.48 (0.34–0.83) | ||||
| Smoking history | 0.244 | 0.009 | 0.158 | 0.625 | |||||
| Yes | 125 (61) | 0.49 (0.33–0.75) | 0.60 (0.42–0.89) | 0.50 (0.34–0.72) | 0.54 (0.39–0.85) | ||||
| No | 81 (39) | 0.46 (0.29–0.60) | 0.47 (0.35–0.69) | 0.44 (0.30–0.68) | 0.52 (0.38–0.85) | ||||
| Histological subtype | 0.072 | 0.053 | 0.029 | 0.005 | |||||
| A | 119 (58) | 0.45 (0.31–0.59) | 0.51 (0.37–0.75) | 0.45 (0.32–0.62) | 0.49 (0.34–0.80) | ||||
| S | 87 (42) | 0.51 (0.35–0.90) | 0.65 (0.39–0.72) | 0.54 (0.34–0.96) | 0.57 (0.42–1.27) | ||||
| TNM stage | 0.209 | 0.001 | 0.001 | 0.002 | |||||
| I | 32 (16) | 0.43 (0.30–0.81) | 0.53 (0.35–0.85) | 0.51 (0.42–0.83) | 0.69 (0.45–0.92) | ||||
| II | 25 (12) | 0.41 (0.35–0.53) | 0.57 (0.42–0.77) | 0.43 (0.28–0.53) | 0.51 (0.30–0.79) | ||||
| III | 84 (40) | 0.51 (0.37–0.76) | 0.60 (0.43–1.04) | 0.56 (0.40–0.78) | 0.59 (0.44–1.06) | ||||
| IV | 65 (32) | 0.45 (0.29–0.59) | 0.46 (0.33–0.69) | 0.36 (0.30–0.68) | 0.45 (0.30–0.59) | ||||
| Lymph node | 0.822 | 0.792 | 0.789 | 0.356 | |||||
| Yes | 143 (69) | 0.48 (0.32–0.63) | 0.55 (0.37–0.83) | 0.47 (0.32–0.68) | 0.51 (0.38–0.85) | ||||
| No | 61 (30) | 0.46 (0.33–0.83) | 0.53 (0.37–0.88) | 0.48 (0.34–0.68) | 0.57 (0.40–0.94) | ||||
| Unknown | 2 | ||||||||
| Distant metastases | 0.126 | 0.007 | 0.007 | 0.001 | |||||
| Yes | 65 (32) | 0.45 (0.29–0.59) | 0.46 (0.33–0.69) | 0.36 (0.29–0.57) | 0.45 (0.30–0.59) | ||||
| No | 141 (68) | 0.49 (0.35–0.76) | 0.59 (0.40–0.90) | 0.52 (0.38–0.76) | 0.59 (0.42–0.95) |
Abbreviations: A, adenocarcinoma; DKK1, dickkopf-1; IQR, inter-quartile range; NSCLC, non-small cell lung cancer; S, squamous cell carcinoma; TNM, tumor-node-metastasis.