Table 2.
Risk factors for incident hypoxic respiratory failure
| Univariable logistic regression
|
Multivariable logistic regression
|
|||
|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Female | 0.92 (0.52–1.61) | 0.76 | 0.53 (0.24–1.17) | 0.12 |
| Age (per 1 year) | 1.01 (0.98–1.05) | 0.42 | 1.02 (0.97–1.07) | 0.40 |
| FEV1 (per 1 L) | 0.08 (0.04–0.17) | <0.0001 | 0.89 (0.03–0.30) | <0.0001 |
| CAT score (per 1 point) | 1.13 (1.08–1.18) | <0.0001 | 1.07 (1.02–1.13) | 0.007 |
| BMI (kg/m2) | ||||
| <22 | 0.41 (0.21–0.78) | 0.007 | 2.25 (0.95–5.33) | 0.07 |
| 22–29 | Ref | Ref | ||
| ≥30 | 0.74 (0.35–1.56) | 0.43 | 1.90 (0.71–5.09) | 0.20 |
| Heart disease | 0.89 (0.35–2.25) | 0.80 | 0.48 (0.14–1.70) | 0.26 |
| Sleep apnea syndrome | 3.59 (1.08–11.9) | 0.037 | 4.79 (0.94–24.3) | 0.06 |
| mMRC* | ||||
| 2 | 1.65 (0.57–4.79) | 0.36 | 0.61 (0.17–2.21) | 0.45 |
| 3 | 2.99 (1.08–8.29) | 0.036 | 0.47 (0.12–1.85) | 0.28 |
| 4 | 11.4 (5.03–25.9) | <0.0001 | 0.84 (0.23–3.04) | 0.79 |
Notes: Results from logistic regression with hypoxic respiratory failure at follow-up as the dependent variable.
*
The estimates of mMRC are from univariable analysis, and multivariable analysis with all independent variables above and with further adjustment for mMRC.
Abbreviations: BMI, body mass index; CAT, COPD assessment test; FEV1, forced expiratory volume in 1 second; mMRC, modified Medical Research Council; OR, odds ratio; Ref, reference category.