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Western blot analysis of protein expression in HT29 cells. (A) Western blot analysis bands of TOPO I, Bax and Caspase-3, and (B) gray-scale quantification of TOPO I, Bax and Caspase-3. **P<0.01, compared with the normal control group; &&P<0.01, the combination treatment group compared with the MA treatment alone group; ##P<0.01, the combination treatment group compared with the CPT-11 treatment alone group. TOPO, topoisomerase; MA, matrine; CPT-11, irinotecan.
