Table I.

Effects of MA and CPT-11 treatment alone and in combination on proliferation of HT29 cells (n=5).

Drug concentration
MA (mg/ml)	CPT-11 (µg/ml)	OD value	Inhibition rate (%)	q-value	Drug-drug interaction
0	0	1.221±0.053	0
0.25	0	1.072±0.086	12.20a
0.5	0	0.892±0.078	26.95a
1	0	0.783±0.025	35.87a
2	0	0.575±0.034	52.91a
0	1.25	0.942±0.063	22.85a
0	2.5	0.765±0.051	37.35a
0	5	0.553±0.027	54.71a
0	10	0.497±0.016	59.29a
0.25	1.25	0.841±0.025	31.08a,b	0.96	Sum
0.5	2.5	0.522±0.042	57.25a,b	1.06	Sum
1	5	0.151±0.012	87.61a,b	1.23	Synergistic
2	10	0.057±0.007	95.29a,b	1.19	Synergistic

^aP<0.01, compared with normal control

^bP<0.01, compared with individual drug treatment alone at the same dose. MA, matrine; CPT-11, irinotecan.