Table II.
Univariate and multivariate COX regression analyses of the effects on overall survival for different patients and characteristics.
| Univariate | ||||
|---|---|---|---|---|
| A, Variable | n | HR | 95% CI | P-value |
| Cofilin (strong vs. weak)a | 310 | 2.15 | 1.32–3.49 | 0.002 |
| ER (positive vs. negative) | 305 | 0.63 | 0.41–0.96 | 0.030 |
| PR (positive vs. negative) | 307 | 0.59 | 0.39–0.92 | 0.019 |
| Her2 (strong vs. weak) | 310 | 1.37 | 0.87–2.16 | 0.177 |
| Ki67 (positive vs. negative) | 310 | 1.22 | 0.79–1.88 | 0.374 |
| Size (>20 mm vs. ≤20 mm) | 304 | 1.45 | 0.85–2.45 | 0.173 |
| Nottingham histological grade (1–3) | 299 | 1.27 | 0.83–1.94 | 0.269 |
| Nodal status (N3, N2, N1, N0) | 304 | 1.39 | 1.12–1.71 | 0.002 |
| Multivariate | ||||
| B, Variable | n | HR | 95% CI | P-value |
| Cofilin (strong vs. weak)a | 299 | 2.22 | 1.35–3.66 | 0.002 |
| ER (positive vs. negative) | 299 | 0.80 | 0.47–1.36 | 0.400 |
| PR (positive vs. negative) | 299 | 0.75 | 0.43–1.32 | 0.323 |
| Nodal status (N3, N2, N1, N0) | 299 | 1.40 | 1.13–1.73 | 0.002 |
a
Cofilin score was dichotomized into weak (0–2) and strong (3). HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor.