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Chemotherapeutic agents enhance Ad5-UPII-E1A-induced necrosis in 5,637 cells. (A) Apoptosis (lower right quadrant) and necrosis (upper right quadrant) detection of the 5,637 cell line treated with Ad5-UPII-E1A and different doses of MMC and HCPT for 72 h. (B) Quantification of apoptosis and necrosis. *P<0.05 vs. Ad5-UPII-E1A alone group. MMC, mitomycin; HCPT, hydroxycamptothecin; Ad5-UPII-E1A, urothelium-specific recombinant adenovirus type 5.
