Table 2.
Meta-analysis summary statistics for the most significantly associated variants with maximal site of JSN and with bone remodelling response phenotypes of hip OA
Study characteristics |
SNP characteristics |
Meta-analysis |
Sex-adjusted meta-analysis |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases definition | Controls definition | N case/control |
SNP | Chr | Position (b37) |
Nearest gene(s) |
EA | EAF case/control |
OR (95% CI) |
p Value | OR (95% CI) |
p Value |
Hip OA with superior JSN | Hip OA with non-superior JSN | 1469/649 | rs754106 | 13 | 47 152 655 | LRCH1 | T | 0.51/0.60 | 0.70 (0.61 to 0.80) | 1.49×10−7 | 0.72 (0.62 to 0.82) | 2.17×10−6 |
Hip OA with axial/medial JSN | Hip OA with non-axial/medial JSN | 501/1617 | rs754106 | 13 | 47 152 655 | LRCH1 | T | 0.61/0.52 | 1.47 (1.27 to 1.70) | 3.66×10−7 | 1.42 (1.22 to 1.65) | 6.92×10−6 |
Hip OA with superior JSN | Hip OA with non-superior JSN | 1469/649 | rs73023563 | 2 | 181 502 830 |
CWC22
UBE2E3 |
T | 0.21/0.14 | 1.59 (1.33 to 1.91) | 6.59×10−7 | 1.58 (1.31 to 1.90) | 1.65×10−6 |
Hip OA with axial/medial JSN | Hip OA with non-axial/medial JSN | 501/1617 | rs73023563 | 2 | 181 502 830 |
CWC22
UBE2E3 |
T | 0.14/0.20 | 0.61 (0.50 to 0.75) | 2.03×10−6 | 0.62 (0.50 to 0.76) | 5.44×10−6 |
Hip OA with axial/medial JSN | Hip OA with non-axial/medial JSN | 501/1617 | rs17050727 | 4 | 121 426 827 | PRDM5 | T | 0.18/0.12 | 1.65 (1.35 to 2.01) | 6.87×10−7 | 1.67 (1.36 to 2.05) | 8.38×10−7 |
Hip OA with hypertrophic response | Hip OA with non-hypertrophic response | 637/1481 | rs6766414 | 3 | 31 488 222 |
STT3B
GADL1 |
G | 0.29/0.22 | 1.45 (1.24 to 1.69) | 3.13×10−6 | 1.46 (1.25 to 1.70) | 2.31×10−6 |
Hip OA with hypertrophic response | Hip OA with non-hypertrophic response | 637/1481 | rs61837881 | 1 | 223 626 562 |
CAPN8
C1orf65 |
C | 0.29/0.22 | 1.44 (1.23 to 1.68) | 4.56×10−6 | 1.43 (1.23 to 1.67) | 5.55×10−6 |
EA, effect allele; EAF, effect allele frequency; JSN, joint space narrowing; OA, osteoarthritis; SNP, single nucleotide polymorphism.