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. 2017 Jun 9;76(7):1199–1206. doi: 10.1136/annrheumdis-2016-210373

Table 2.

Meta-analysis summary statistics for the most significantly associated variants with maximal site of JSN and with bone remodelling response phenotypes of hip OA

Study characteristics
SNP characteristics
Meta-analysis
Sex-adjusted meta-analysis
Cases definition Controls definition N
case/control
SNP Chr Position
(b37)
Nearest
gene(s)
EA EAF
case/control
OR
(95% CI)
p Value OR
(95% CI)
p Value
Hip OA with superior JSN Hip OA with non-superior JSN 1469/649 rs754106 13 47 152 655 LRCH1 T 0.51/0.60 0.70 (0.61 to 0.80) 1.49×10−7 0.72 (0.62 to 0.82) 2.17×10−6
Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 501/1617 rs754106 13 47 152 655 LRCH1 T 0.61/0.52 1.47 (1.27 to 1.70) 3.66×10−7 1.42 (1.22 to 1.65) 6.92×10−6
Hip OA with superior JSN Hip OA with non-superior JSN 1469/649 rs73023563 2 181 502 830 CWC22
UBE2E3
T 0.21/0.14 1.59 (1.33 to 1.91) 6.59×10−7 1.58 (1.31 to 1.90) 1.65×10−6
Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 501/1617 rs73023563 2 181 502 830 CWC22
UBE2E3
T 0.14/0.20 0.61 (0.50 to 0.75) 2.03×10−6 0.62 (0.50 to 0.76) 5.44×10−6
Hip OA with axial/medial JSN Hip OA with non-axial/medial JSN 501/1617 rs17050727 4 121 426 827 PRDM5 T 0.18/0.12 1.65 (1.35 to 2.01) 6.87×10−7 1.67 (1.36 to 2.05) 8.38×10−7
Hip OA with hypertrophic response Hip OA with non-hypertrophic response 637/1481 rs6766414 3 31 488 222 STT3B
GADL1
G 0.29/0.22 1.45 (1.24 to 1.69) 3.13×10−6 1.46 (1.25 to 1.70) 2.31×10−6
Hip OA with hypertrophic response Hip OA with non-hypertrophic response 637/1481 rs61837881 1 223 626 562 CAPN8
C1orf65
C 0.29/0.22 1.44 (1.23 to 1.68) 4.56×10−6 1.43 (1.23 to 1.67) 5.55×10−6

EA, effect allele; EAF, effect allele frequency; JSN, joint space narrowing; OA, osteoarthritis; SNP, single nucleotide polymorphism.