Table 1.

Mouse weight and laboratory parameters

	WT-CTRL	WT-CKD	SOST-KO-CTRL	SOST-KO-CKD	P WT-CTRL versus SOST-KO-CTRL	P WT-CTRL versus WT-CKD	P SOST-KO-CTRL versus SOST-KO-CKD	P for interaction (2-way ANOVA)
Weight (g)	24.8 ± 1.2	20.8 ± 3.4	28.3 ± 1.6	24.1 ± 1.9	<0.001	<0.001	<0.001	0.8
Creatinine (mg/dl)	0.25 (0.21 – 0.27)	0.45 (0.42–0.54)	0.27 (0.21–0.29)	0.35 (0.29–0.43)	0.4	<0.001	<0.001	0.004
BUN (mg/dl)	25 ± 4	89 ± 21	24 ± 3	75 ± 26	0.7	<0.001	<0.001	0.08
Calcium (mmol/l)	2.56 ± 0.18	3.02 ± 0.07	2.65 ± 0.10	2.88 ± 0.12	0.3	<0.001	0.002	0.02
Albumin (g/l)	38 ± 5	38 ± 2	37 ± 1	38 ± 2	0.7	0.8	0.3	0.5
Phosphorus (mmol/l)	1.77 ± 0.46	1.92 ± 0.37	1.92 ± 0.33	1.99 ± 0.35	0.3	0.2	0.6	0.6
PTH (pg/ml)	264 (119–314)	274 (70–833)	150 (105–245)	151 (101–271)	0.2	0.5	0.4	0.8

ANOVA, analysis of variance; BUN, blood urea nitrogen; CKD, chronic kidney disease; CTRL, control; PTH, parathyroid hormone; SOST, sclerostin.

Data are shown as mean ± SD or median (25th to 75th percentiles).