Table 2.
μCT of the tibia-cortical regions
| WT-CTRL | WT-CKD | SOST-KO-CTRL | SOST-KO-CKD | P WT-CTRL versus SOST-KO-CTRL | P WT-CTRL versus WT-CKD | P SOST-KO-CTRL versus SOST-KO-CKD | P for interaction (2-way ANOVA) | |
|---|---|---|---|---|---|---|---|---|
| Diaphysis | ||||||||
| Ct.Th (μm) | 247 ± 160 | 205 ± 23 | 484 ± 54 | 430 ± 57 | <0.001 | <0.001 | 0.01 | 0.5 |
| Ct.Po (%) | 3.3 (2.9–3.5) | 3.8 (3.4–4.9) | 1.7 (1.6–2.1) | 2.2 (1.8–2.3) | <0.001 | 0.003 | 0.009 | 0.7 |
| Mineral density (mg HA/cm3) | 1390 ± 82 | 1384 ± 96 | 1434 ± 64 | 1410 ± 57 | 0.1 | 0.8 | 0.3 | 0.6 |
| Periosteal perimeter (mm) | 4.29 (4.21 –4.73) | 4.45 (4.15– 4.74) | 5.86 (5.58 –5.96) | 6.01 (5.85–6.15) | <0.001 | 0.9 | 0.5 | 0.5 |
| Marrow area (mm2) | 0.26 (0.24–0.32) | 0.38 (0.31–0.41) | 0.09 (0.07–0.26) | 0.26 (0.22–0.32) | <0.001 | 0.01 | 0.002 | 0.025 |
| CSMI (mm4) | 0.14 (0.13–0.19) | 0.14 (0.11–0.17) | 0.41 (0.39–0.44) | 0.44 (0.41–0.51) | <0.001 | 0.2 | 0.9 | 0.4 |
| Metaphysis | ||||||||
| Ct.Th (μm) | 182 ± 15.4 | 163 ± 27 | 318 ± 23.9 | 307 ± 33.4 | <0.001 | 0.01 | 0.3 | 0.5 |
| Ct.Po (%) | 9.1 ± 1.2 | 12.3 ± 3.5 | 2.8 ± 0.7 | 3.0 ± 1.0 | <0.001 | <0.001 | 0.5 | 0.005 |
| Mineral density (mg HA/cm3) | 1243 ± 46 | 1098 ± 94 | 1342 ± 106 | 1279 ± 38 | <0.001 | <0.001 | 0.03 | 0.025 |
ANOVA, analysis of variance; CKD, chronic kidney disease; CSMI, cross-sectional moment of inertia, polar; Ct.Po, cortical porosity; CTRL, control; Ct.Th, cortical thickness; KO, knockout; mg HA, mg hydroxyapatite; SOST, sclerostin; WT, wild-type.
Data are shown as mean ±SD or median (25th to 75th percentiles).