Table 3.
μCT of the tibia-trabecular region (metaphysis)
| WT-CTRL | WT-CKD | SOST-KO-CTRL | SOST-KO-CKD | P WT-CTRL versus SOST-KO-CTRL | P WT-CTRL versus WT-CKD | P SOST-K OCTRL versus SOST-KO-CKD | P for interaction (2-way ANOVA) | |
|---|---|---|---|---|---|---|---|---|
| BV/TV (%) | 3.7 ± 1.3 | 5.4 ± 1.9 | 40.1 ±11.5 | 39.9 ± 13.6 | <0.001 | 0.003 | 0.9 | 0.6 |
| Tb.N (1/mm) | 2.07 (1.89–2.45) | 2.23 (1.91–2.42) | 3.43 (3.17–4.58) | 3.42 (2.63–3.97) | <0.001 | 0.6 | 0.3 | 0.2 |
| Tb.Th (μm) | 0.048 (0.031–0.052) | 0.047 (0.019–0.051) 0.107 | (0.054–0.116) | 0.053 (0.047–0.068) | <0.001 | 0.2 | 0.009 | 0.3 |
| Tb.Sp (μm) | 484 ± 72 | 487 ± 80 | 285 ± 85 | 323 ± 84 | <0.001 | 0.9 | 0.2 | 0.3 |
| Tb1/NSD | 0.18 ± 0.03 | 0.18 ± 0.04 | 0.15 ± 0.05 | 0.16 ± 0.05 | 0.04 | 0.9 | 0.5 | 0.5 |
| Mineral density (mg HA/cm3) | 1131 ± 41 | 1026 ± 58 | 1170 ± 77 | 1101 ± 38 | 0.1 | <0.001 | 0.017 | 0.053 |
| SMI | 2.9 ± 0.4 | 2.5 ± 0.3 | 0.4 ± 0.8 | 0.9 ± 0.7 | <0.001 | <0.001 | 0.08 | 0.001 |
ANOVA, analysis of variance; BV/TV, bone volume/total volume; CKD, chronic kidney disease; CTRL, control; mg HA, mg hydroxyapatite; NSD, standard deviation of trabecular number; SMI, structure model index; μCT, micro computed tomography; SOST, sclerostin; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Tb1/NSD, SD of 1/trabecular number; WT, wild-type.
Data are shown as mean ±SD or median (25th to 75th percentiles).