Table 2.

Diagnostic performance of faecal immunochemical test (FIT), marker Fusobacterium nucleatum (Fn) and the combined test for colorectal cancer (CRC) and advanced adenoma

Marker/AUC	Discovery cohort	Validation cohort	All samples
CRC model
FIT	0.86 (0.81–0.90)	0.85 (0.76–0.94)	0.85 (0.81–0.89)
Fn	0.83 (0.78–0.89)	0.89 (0.80–0.98)	0.85 (0.80–0.90)
FIT+Fn	0.95 (0.92–0.98)	0.96 (0.92–0.99)	0.95 (0.92–0.98)
(FIT+Fn) vs FIT	p<0.001	p=0.0014	p<0.001
Advanced adenoma model
FIT	0.57 (0.53–0.61)	0.56 (0.51–0.61)	0.56 (0.53–0.59)
Fn	0.59 (0.51–0.67)	0.58 (0.49–0.67)	0.59 (0.53–0.65)
FIT+Fn	0.65 (0.58–0.73)	0.63 (0.55–0.72)	0.65 (0.59–0.70)
(FIT+Fn) vs FIT	p=0.007	p=0.031	p<0.001

The AUC values of the discovery cohort, the validation cohort and the combined cohort were shown, fitting the logistic regression model from the discovery cohort. The one-sided Delong's test was used to test for incremental gain in AUC for the combined test over FIT.

AUC, area under the receiver-operating characteristic curve.