Table 2.
Association of industry financial COI and outcome (dependent variable), after univariable binomial logistic regression
| COI (any author, n studies) | Favorable outcomes, n (%) | Unadjusted OR for a favorable outcome (95% CI) | p value |
|---|---|---|---|
| Grants (182) | 104 (57) | 2.05 (1.42–2.96) | <0.01 |
| Personal fee (200) | 110 (55) | 1.85 (1.29–2.65) | <0.01 |
| Financial support (110) | 59 854) | 1.50 (0.98–2.29) | 0.06 |
| Other (99) | 66 (67) | 2.91 (1.83–4.62) | <0.01 |
| Pending patent (16) | 10 (63) | 2.02 (0.72–5.64) | 0.18 |
| Issued patent (15) | 10 (67) | 2.43 (0.82–7.22) | 0.11 |
| Licensed patent (19) | 11 (58) | 1.66 (0.66–4.20) | 0.28 |
| Royalties (8) | 3 (38) | 0.71 (0.17–2.99) | 0.64 |
| Stock ownership (81) | 61 (75) | 4.54 (2.64–7.80) | <0.01 |
| Employee (126) | 82 (65) | 2.86 (1.88–4.36) | <0.01 |
| Funding source | |||
| Non-profit (244) | 93 (38) | Reference | |
| Mixed (117) | 47 (40) | 2.51 (1.53–4.14) | <0.01 |
| For-profit (148) | 93 (63) | 2.74 (1.80–4.19) | <0.01 |
COI conflict of interest