Fig. 1.

Voxel selection and representative examples of ³¹P and ¹H magnetic resonance (MR) spectra. a Voxel selection of ³¹P-MR spectra displayed on sagittal (left) and coronal (right) anatomical images: anterior cingulate cortex (blue), retrosplenial cortex (yellow), left and right hippocampus (purple). The nominal voxel size is indicated by squares, and the approximation of the effective spherical voxel size is indicated by circles. b Representative ³¹P-MR spectrum from the retrosplenial cortex. Zero-filling to 4096 data points and an 8-Hz Gaussian filter were applied. c Sagittal (left) and transversal (right) anatomical images showing single-voxel volumes of ¹H-MR spectra in anterior cingulate cortex (blue), posterior cingulate cortex (yellow), and voxel selection of left and right hippocampi (purple). d Representative ¹H-MR spectrum from the posterior cingulate cortex. Zero-filling to 8192 data points and a 2-Hz Lorentzian filter were applied. PEth, Phosphoethanolamine; PCh, Phosphocholine; Pi, Inorganic phosphate; GPEth, Glycerophosphoethanolamine; GPCh, Glycerophosphocholine; MP, Membrane phospholipids; PCr, Phosphocreatine; ATP, Adenosine triphosphate; NAD(H), Nicotinamide adenine dinucleotide; ppm, Parts per million; NAA, N-acetyl-aspartate; tCho, Choline-containing compounds; tCr, Total creatine; mI, Myo-inositol