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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Arthritis Rheumatol. 2016 Jun;68(6):1511–1521. doi: 10.1002/art.39600

Figure 1.

Figure 1

Panel A: Acute PGB treatment (14 days) in FM independently decreases insular GMV bilaterally (analysis 1). Panel B: The greatest decreases in GMV between PGB and PBO treatments are seen in the right medial frontal gyrus (analysis 2). Panel C: Decreases in medial frontal gyrus GMV in the PGB cohort is associated with decreases in MPQ total and sensory pain subscale scores (analysis 2). Black lines with filled in circles indicate individual PGB subject changes in GMV. Black lines with empty circles indicate GMV changes during the PBO period. Red lines indicate group means. Abbreviations: FM= Fibromyalgia GMV= Gray Matter Volume; MPQ= McGill Pain Questionnaire; PGB= Pregabalin; PBO= Placebo; SVC= Small Volume Correction.