. Author manuscript; available in PMC: 2017 Jul 27.

Published in final edited form as: Arthritis Rheumatol. 2016 Jun;68(6):1511–1521. doi: 10.1002/art.39600

Table 3.

Changes in VBM and evoked-pain connectivity metrics are associated with decreased clinical pain

Brain Region(s)	Clinical Measure	r - value	p - value
PGB GMV Decreases from Analysis 2 Correlated to Decreases in Clinical Pain
Medial Frontal Gyrus	Difference in McGill Total Score	.545	.029^**
Medial Frontal Gyrus	Difference in McGill Sensory Score	.526	.037^**
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 3 Correlated to Decreases in Clinical Pain
Right Posterior Insula to Thalamus	Difference in VAS Score	.506	.065^*
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 4 Correlated to Decreases in Clinical Pain
Left Posterior Insula to Middle/Medial Frontal Gyrus	Difference in McGill Total Score	.603	.017^**
Left Posterior Insula to Middle/Medial Frontal Gyrus	Difference in McGill Sensory Score	.601	.018^**
PGB Evoked-Pain Connectivity fMRI Increases from Analysis 4 Correlated to Decreases in Clinical Pain
Precentral/Postcentral Gyrus to Posterior Cingulate/Precuneus	Difference in VAS Score	−.637	.019^**
Left Posterior Insula to Middle Temporal Gyrus	Difference in McGill Affective Score	−.537	.039^**

Differences in GMV, evoked-pain connectivity metrics, and clinical measures are calculated as post minus pre values; Abbreviations: fMRI= functional Magnetic Resonance Imaging; PGB= Pregabalin; VAS= Visual Analog Scale;

indicates trend (p < .1);

^**

indicates significant correlation (p < .05).