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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Arthritis Rheumatol. 2016 Jun;68(6):1511–1521. doi: 10.1002/art.39600

Table 3.

Changes in VBM and evoked-pain connectivity metrics are associated with decreased clinical pain

Brain Region(s) Clinical Measure r - value p - value
PGB GMV Decreases from Analysis 2 Correlated to Decreases in Clinical Pain
Medial Frontal Gyrus Difference in McGill Total Score .545 .029**
Difference in McGill Sensory Score .526 .037**
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 3 Correlated to Decreases in Clinical Pain
Right Posterior Insula to Thalamus Difference in VAS Score .506 .065*
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 4 Correlated to Decreases in Clinical Pain
Left Posterior Insula to Middle/Medial Frontal Gyrus Difference in McGill Total Score .603 .017**
Difference in McGill Sensory Score .601 .018**
PGB Evoked-Pain Connectivity fMRI Increases from Analysis 4 Correlated to Decreases in Clinical Pain
Precentral/Postcentral Gyrus to Posterior Cingulate/Precuneus Difference in VAS Score −.637 .019**
Left Posterior Insula to Middle Temporal Gyrus Difference in McGill Affective Score −.537 .039**

Differences in GMV, evoked-pain connectivity metrics, and clinical measures are calculated as post minus pre values; Abbreviations: fMRI= functional Magnetic Resonance Imaging; PGB= Pregabalin; VAS= Visual Analog Scale;

*

indicates trend (p < .1);

**

indicates significant correlation (p < .05).