Table 3.
Brain Region(s) | Clinical Measure | r - value | p - value |
---|---|---|---|
PGB GMV Decreases from Analysis 2 Correlated to Decreases in Clinical Pain | |||
Medial Frontal Gyrus | Difference in McGill Total Score | .545 | .029** |
Difference in McGill Sensory Score | .526 | .037** | |
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 3 Correlated to Decreases in Clinical Pain | |||
Right Posterior Insula to Thalamus | Difference in VAS Score | .506 | .065* |
PGB Evoked-Pain Connectivity fMRI Decreases from Analysis 4 Correlated to Decreases in Clinical Pain | |||
Left Posterior Insula to Middle/Medial Frontal Gyrus | Difference in McGill Total Score | .603 | .017** |
Difference in McGill Sensory Score | .601 | .018** | |
PGB Evoked-Pain Connectivity fMRI Increases from Analysis 4 Correlated to Decreases in Clinical Pain | |||
Precentral/Postcentral Gyrus to Posterior Cingulate/Precuneus | Difference in VAS Score | −.637 | .019** |
Left Posterior Insula to Middle Temporal Gyrus | Difference in McGill Affective Score | −.537 | .039** |
Differences in GMV, evoked-pain connectivity metrics, and clinical measures are calculated as post minus pre values; Abbreviations: fMRI= functional Magnetic Resonance Imaging; PGB= Pregabalin; VAS= Visual Analog Scale;
indicates trend (p < .1);
indicates significant correlation (p < .05).