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Blocking mutant p53/DAB2IP interaction inhibits the oncogenic response to insulin without affecting the expression of INSRs (related to Fig. 4). MDA-MB231 cells were stably transduced with retroviruses expressing the EGFP-DAB2IP(1–186)KA2 fusion protein (EGFP-KA2) or EGFP alone. Expression of INSR A/B and IGF1R was measured by RT-qPCR (mean ± SEM; n = 3). Expression of EGFPs was analyzed by Western blot. ns, statistically not significant at P > 0.05.
