Fig. 2.

Molecular divergence of sand rat Pdx1. (A) Alignment of Pdx1 hexapeptide domain and homeodomain sequences across vertebrates. (B) Maximum likelihood tree of ParaHox proteins showing divergent P. obesus Pdx1; species included are sand rat, mouse, zebra finch, spotted gar, amphioxus (full tree in SI Appendix, Fig. S6). (C) Histogram of PDI values for 1:1:1 mammalian orthologs of the sand rat predicted proteins: Pdx1 is marked by an arrow, other genes within the GC-rich region are marked by arrowheads.