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. 2017 Jul 6;114(29):E5930–E5939. doi: 10.1073/pnas.1705206114

Fig. 5.

Fig. 5.

BRAF inhibition up-regulates miR-211–5p expression by regulating the survival pathways. (A) Immunoblotting of genes involved in survival pathways. The images are representative of three individual experiments. GAPDH was used as the loading control for the cells. (B) Fold change expression of differentiation genes as well as TRPM1 and MITF genes upon vemurafenib treatment as measured by qPCR. GAPDH was used as the internal control (n = 3). (C) Flowchart showing the up-regulation of miR-211–5p upon vemurafenib treatment. Data are presented as ± SEM. *P < 0.05, **P < 0.01. NT, nontreated; ns, nonsignificant; T, treated; wrt, with respect to.