Table 1.

The effect of different preparation methods on physicochemical properties of blank PCL and mePEG-PCL nanoparticles (n = 3 ± SD).

		Mean diameter ± SD (nm)	PDI ± SD	Zeta potential ± SD (mV)
PCL nanoparticles	nanoprecipitation	168 ± 3	0.10 ± 0.02	−17 ± 0.4
	emulsification/solvent evaporation	184 ± 3	0.29 ± 0.4	−18 ± 0.8
	double emulsion	352 ± 2	0.39 ± 0.02	−8 ± 0.1
mePEG-PCL nanoparticles	nanoprecipitation	77 ± 3	0.17 ± 0.04	−13 ± 3.2
	emulsification/solvent evaporation	146 ± 3	0.27 ± 0.004	−19 ± 1.3
	double emulsion	170 ± 2	0.19 ± 0.01	−5 ± 0.24