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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Cancer Prev Res (Phila). 2017 May 3;10(7):377–388. doi: 10.1158/1940-6207.CAPR-17-0015

Figure 2. Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer.

Figure 2

A, Experimental scheme for the AOM/DSS-induced colon carcinogenesis model. C57Bl/6J mice provided water (Control) or water containing sildenafil (5.7mg/kg/day). B, Change in body weight from the initial weight. AOM was administered on day 0, and grey panels depict DSS treatment cycles. C, Representative colons from AOM/DSS treated mice, top-bottom orientation is proximal-rectal and representative polyps are indicated in the first panels by arrows. D, Plot shows the effect of sildenafil on median polyp number per animal (n=14 per group). Asterisks show difference between weight loss between treated and control groups at each day, p < 0.0001; Panel D, p-value generated with Mann–Whitney test.