Table 1. MIC values for kanamycin and flexicates [Fe2 L n 3]Cl4 (n = 2a–2e) against MRSA and E. coli, over 20 h at 37 °C in Müller–Hinton broth. The approximate concentrations in μM are included for comparison with IC50 data from cancer cell line testing.
Compound | MRSA MIC |
E. coli MIC |
||
(μg ml–1) | (μM) | (μg ml–1) | (μM) | |
Kanamycin | 1 | 2 | 2 | 4 |
ΛFe-[Fe2 L2a 3]Cl4 | 64 | 35 | >128 | 70 |
ΛFe-[Fe2 L2b 3]Cl4 | 128 | 70 | >128 | 70 |
ΛFe-[Fe2 L2c 3]Cl4 | 128 | 70 | >128 | 70 |
ΛFe-[Fe2 L2d 3]Cl4 | >128 | 70 | 64 | 35 |
ΛFe-[Fe2 L2e 3]Cl4 | 64 | 35 | 128 | 70 |