Table S3.

The GO BP functional analysis of Module 2

GO BP term	Count	P-value
GO:0036499~PERK-mediated unfolded protein response	3	9.81E–06
GO:1990440~positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	3	9.81E–06
GO:0071850~mitotic cell cycle arrest	3	1.16E–05
GO:0007050~cell cycle arrest	3	0.0014
GO:0036500~ATF6-mediated unfolded protein response	2	0.0037
GO:0006983~ER overload response	2	0.0042
GO:0043065~positive regulation of apoptotic process	3	0.0063
GO:0034198~cellular response to amino acid starvation	2	0.0104
GO:2000379~positive regulation of reactive oxygen species metabolic process	2	0.0124
GO:0071479~cellular response to ionizing radiation	2	0.0129
GO:0043066~negative regulation of apoptotic process	3	0.0141
GO:0034605~cellular response to heat	2	0.0153
GO:0000079~regulation of cyclin-dependent protein serine/threonine kinase activity	2	0.0161
GO:0042542~response to hydrogen peroxide	2	0.0211
GO:0070373~negative regulation of ERK1 and ERK2 cascade	2	0.0239
GO:0043433~negative regulation of sequence-specific DNA binding transcription factor activity	2	0.0247
GO:0006977~DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2	0.0256
GO:0006979~response to oxidative stress	2	0.0450

Note: Count refers to the number of DEGs enriched in the GO BP term.

Abbreviations: ATF6, activating transcription factor 6; BP, biological process; DEGs, differentially expressed genes; ER, endoplasmic reticulum; ERK1, extracellular signal-regulated kinases 1; ERK2, extracellular signal-regulated kinases 2; GO, Gene Ontology; PERK, protein kinase R-like endoplasmic reticulum kinase.