Table 2.
Top 35 predominant BP terms and all the eight CC terms and MF terms in GO functional enrichment analysis
| Category | Term | Count | P-value |
|---|---|---|---|
| GO BP | GO:0006986~response to unfolded protein | 9 | 5.85E–05 |
| GO:0007568~aging | 16 | 3.79E–04 | |
| GO:0046677~response to antibiotic | 7 | 5.47E–04 | |
| GO:0042981~regulation of apoptotic process | 18 | 7.22E–04 | |
| GO:0090200~positive regulation of release of cytochrome c from mitochondria | 6 | 0.0020 | |
| GO:0042149~cellular response to glucose starvation | 6 | 0.0024 | |
| GO:0007565~female pregnancy | 10 | 0.0026 | |
| GO:0042493~response to drug | 21 | 0.0027 | |
| GO:0090090~negative regulation of canonical Wnt signaling pathway | 14 | 0.0030 | |
| GO:0048661~positive regulation of smooth muscle cell proliferation | 8 | 0.0035 | |
| GO:0090084~negative regulation of inclusion body assembly | 4 | 0.0036 | |
| GO:0006950~response to stress | 8 | 0.0038 | |
| GO:0001666~response to hypoxia | 14 | 0.0047 | |
| GO:0042594~response to starvation | 6 | 0.0055 | |
| GO:2000483~negative regulation of interleukin-8 secretion | 3 | 0.0062 | |
| GO:0036499~PERK-mediated unfolded protein response | 4 | 0.0063 | |
| GO:1990440~positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 4 | 0.0063 | |
| GO:0001836~release of cytochrome c from mitochondria | 5 | 0.0063 | |
| GO:0051090~regulation of sequence-specific DNA binding transcription factor activity | 5 | 0.0085 | |
| GO:0002009~morphogenesis of an epithelium | 4 | 0.0099 | |
| GO:0019626~short-chain fatty acid catabolic process | 3 | 0.0102 | |
| GO:0043065~positive regulation of apoptotic process | 19 | 0.0109 | |
| GO:0042026~protein refolding | 4 | 0.0121 | |
| GO:0006915~apoptotic process | 30 | 0.0136 | |
| GO:0050679~positive regulation of epithelial cell proliferation | 7 | 0.0139 | |
| GO:0072655~establishment of protein localization to mitochondrion | 3 | 0.0149 | |
| GO:0006977~DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 7 | 0.0162 | |
| GO:0097193~intrinsic apoptotic signaling pathway | 5 | 0.0163 | |
| GO:0044344~cellular response to fibroblast growth factor stimulus | 5 | 0.0163 | |
| GO:0044849~estrous cycle | 4 | 0.0172 | |
| GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 7 | 0.0187 | |
| GO:0042127~regulation of cell proliferation | 13 | 0.0199 | |
| GO:0032496~response to lipopolysaccharide | 12 | 0.0202 | |
| GO:0050873~brown fat cell differentiation | 5 | 0.0203 | |
| GO:0009408~response to heat | 6 | 0.0205 | |
| GO-CC | GO:0005739~mitochondrion | 83 | 7.17E–08 |
| GO:0070062~extracellular exosome | 143 | 2.50E–07 | |
| GO:0005759~mitochondrial matrix | 31 | 7.53E–07 | |
| GO:0005615~extracellular space | 65 | 0.0034 | |
| GO:0005777~peroxisome | 10 | 0.0086 | |
| GO:0000502~proteasome complex | 7 | 0.0154 | |
| GO:0022624~proteasome accessory complex | 4 | 0.0183 | |
| GO:0005829~cytosol | 130 | 0.0402 | |
| GO-MF | GO:0005515~protein binding | 339 | 4.72E–04 |
| GO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 5 | 0.0070 | |
| GO:0016787~hydrolase activity | 14 | 0.0138 | |
| GO:0051087~chaperone binding | 8 | 0.0202 | |
| GO:0008046~axon guidance receptor activity | 3 | 0.0216 | |
| GO:0051082~unfolded protein binding | 9 | 0.0340 | |
| GO:0046703~natural killer cell lectin-like receptor binding | 3 | 0.0355 | |
| GO:0016791~phosphatase activity | 5 | 0.0461 |
Note: Count refers to the number of DEGs enriched in the GO term.
Abbreviations: BP, biological process; CC, cellular component; DEGs, differentially expressed genes; GO, Gene Ontology; MF, molecular function; PERK, protein kinase R-like endoplasmic reticulum kinase.