Table 3.
GO enrichment analysis of the target genes of miR-133a-3p
| Category | Term | Count | % | P-value | |
|---|---|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0006509 | Membrane protein ectodomain proteolysis | 6 | 0.007358532 | 9.84E–05 |
| GOTERM_BP_DIRECT | GO:0032964 | Collagen biosynthetic process | 3 | 0.003679266 | 0.004966407 |
| GOTERM_BP_DIRECT | GO:0006979 | Response to oxidative stress | 7 | 0.008584954 | 0.007494953 |
| GOTERM_BP_DIRECT | GO:0031623 | Receptor internalization | 5 | 0.00613211 | 0.009738182 |
| GOTERM_BP_DIRECT | GO:0007264 | Small GTPase mediated signal transduction | 13 | 0.015943486 | 0.010401849 |
| GOTERM_BP_DIRECT | GO:0046777 | Protein autophosphorylation | 9 | 0.011037798 | 0.015688851 |
| GOTERM_BP_DIRECT | GO:0048280 | Vesicle fusion with Golgi apparatus | 3 | 0.003679266 | 0.016393286 |
| GOTERM_BP_DIRECT | GO:0045931 | Positive regulation of mitotic cell cycle | 4 | 0.004905688 | 0.01978581 |
| GOTERM_BP_DIRECT | GO:0032456 | Endocytic recycling | 4 | 0.004905688 | 0.022591642 |
| GOTERM_BP_DIRECT | GO:0030217 | T cell differentiation | 4 | 0.004905688 | 0.02560231 |
| GOTERM_BP_DIRECT | GO:2000036 | Regulation of stem cell population maintenance | 3 | 0.003679266 | 0.027032891 |
| GOTERM_BP_DIRECT | GO:0051292 | Nuclear pore complex assembly | 3 | 0.003679266 | 0.027032891 |
| GOTERM_BP_DIRECT | GO:0000910 | Cytokinesis | 4 | 0.004905688 | 0.032235851 |
| GOTERM_BP_DIRECT | GO:0030048 | Actin filament-based movement | 3 | 0.003679266 | 0.0331441 |
| GOTERM_BP_DIRECT | GO:0072659 | Protein localization to plasma membrane | 5 | 0.00613211 | 0.034128257 |
| GOTERM_BP_DIRECT | GO:0015031 | Protein transport | 6 | 0.007358532 | 0.037343901 |
| GOTERM_BP_DIRECT | GO:2001241 | Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 3 | 0.003679266 | 0.039735772 |
| GOTERM_BP_DIRECT | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 3 | 0.003679266 | 0.046774564 |
| GOTERM_BP_DIRECT | GO:0071560 | Cellular response to transforming growth factor beta stimulus | 4 | 0.004905688 | 0.047906842 |
| GOTERM_CC_DIRECT | GO:0070062 | Extracellular exosome | 96 | 0.117736515 | 1.58E–06 |
| GOTERM_CC_DIRECT | GO:0005925 | Focal adhesion | 23 | 0.028207707 | 3.54E–05 |
| GOTERM_CC_DIRECT | GO:0005829 | Cytosol | 42 | 0.051509726 | 0.002077235 |
| GOTERM_CC_DIRECT | GO:0043209 | Myelin sheath | 10 | 0.01226422 | 0.006631547 |
| GOTERM_CC_DIRECT | GO:0016020 | Membrane | 37 | 0.045377615 | 0.008847182 |
| GOTERM_CC_DIRECT | GO:0001931 | Uropod | 3 | 0.003679266 | 0.015496611 |
| GOTERM_CC_DIRECT | GO:0005654 | Nucleoplasm | 50 | 0.061321102 | 0.016133224 |
| GOTERM_CC_DIRECT | GO:0001726 | Ruffle | 6 | 0.007358532 | 0.017212833 |
| GOTERM_CC_DIRECT | GO:0030175 | Filopodium | 5 | 0.00613211 | 0.020498143 |
| GOTERM_CC_DIRECT | GO:0019898 | Extrinsic component of membrane | 6 | 0.007358532 | 0.0245113 |
| GOTERM_CC_DIRECT | GO:0005739 | Mitochondrion | 33 | 0.040471927 | 0.025783112 |
| GOTERM_CC_DIRECT | GO:0005902 | Microvillus | 5 | 0.00613211 | 0.026546689 |
| GOTERM_CC_DIRECT | GO:0005802 | Trans-Golgi network | 8 | 0.009811376 | 0.02787919 |
| GOTERM_CC_DIRECT | GO:0016324 | Apical plasma membrane | 10 | 0.01226422 | 0.028054824 |
| GOTERM_CC_DIRECT | GO:0005794 | Golgi apparatus | 22 | 0.026981285 | 0.029322169 |
| GOTERM_CC_DIRECT | GO:0005884 | Actin filament | 5 | 0.00613211 | 0.038776107 |
| GOTERM_MF_DIRECT | GO:0005524 | ATP binding | 52 | 0.063773946 | 0.001227934 |
| GOTERM_MF_DIRECT | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | 12 | 0.014717064 | 0.004972384 |
| GOTERM_MF_DIRECT | GO:0004674 | Protein serine/threonine kinase activity | 14 | 0.017169909 | 0.007071712 |
| GOTERM_MF_DIRECT | GO:004482 | 2poly(A) RNA binding | 34 | 0.041698349 | 0.021519286 |
| GOTERM_MF_DIRECT | GO:000154 | Beta-amyloid binding | 4 | 0.004905688 | 0.024757557 |
Abbreviation: GO, gene ontology.