Figure 2.

Prognostic and expression analysis of phosphorylated AKT (pAKT) overexpression (pAKT^high) in diffuse large B-cell lymphoma (DLBCL) with and without Myc, Bcl-2, and phosphorylated STAT3 (pSTAT3) overexpression, as shown by the Kaplan-Meier curves and scatter plots. The cutoffs for Bcl-2^high, Myc^high, and pSTAT3^high were ≥70%, ≥70%, and ≥50%, respectively. A: In the Bcl-2^low subset, but not Bcl-2^high subset, pAKT^high is associated with significantly worse progression-free survival (PFS). However, in both Bcl-2^low and Bcl-2^high subsets, Myc expression is significantly higher in the pAKT^high group than in the pAKT^low group. Within the Bcl-2^low and Bcl-2^high subsets, Bcl-2 expression does not show much difference between the pAKT^high and pAKT^low groups. B: In the Myc^low, but not the Myc^high subset, pAKT^high is associated with significantly worse PFS. However, in the Myc^low subset, both Myc and Bcl-2 levels are significantly higher in the pAKT^high group than in the pAKT^low group. C: In the pSTAT3^low subset, but not the pSTAT3^high subset, pAKT^high is associated with significantly worse PFS. However, in the pSTAT3^low subset, both Myc and Bcl-2 levels are significantly higher in the pAKT^high group than in the pAKT^low group. D: In the non – double-positive (DP) subset but not in the Myc^high/Bcl-2^high (DP) subset, pAKT^high is associated with significantly worse PFS. However, in the non-DP subset, both Myc and Bcl-2 levels are significantly higher in the pAKT^high group than in the pAKT^low group. In the scatter plots, each dot represents the expression level in one patient. The mean expression levels in the pAKT^low group are indicated by blue lines; the mean expression levels in the pAKT^low group are indicated by pink lines. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001.