Table 4.
Genes Significantly Differentially Expressed between p-AKThigh and p-AKTlow Cases in Overall DLBCL and in GCB-DLBCL
| Functional categories | In DLBCL (FDR < 0.01) |
In GCB-DLBCL (FDR < 0.05) |
|
|---|---|---|---|
| Down-regulated genes | Down-regulated genes | Up-regulated genes | |
| Immune response, cytokine receptors, chemokine | C1S, IL1R1 | CFH/CFHR1, C3, C1S, CCL5, IFNGR1, CEBPD, HLA-B, B2M, HLA-F, C2, HLA-A, HLA-E, HLA-G | DEFB126 |
| Apoptosis | CARD16/CASP1, VDAC3, TMBIM6 | MDM2 | |
| Signaling | NBL1 | CD63, SEL1L, PRKAR1A, WDR26, EFHD2, NBL1 | MAP2K5, TSSK3 |
| Gene expression, cell growth | ZNF583, JUN, DUSP1, CALD1 | DUSP1, AEBP1, JUN, KLF9, RBPJ, NR3C1, GRN, LMNA, RUNX1, HNRNPU | RPL37A, ANAPC13, SNAI3, MRTO4, CEP97, HNRNPR, TTF2 |
| Cell adhesion, cytoskeleton, extracellular matrix, exocytosis, migration, metastasis, angiogenesis | TIMP2, COL6A1, COL1A2, DCN, COL1A1, COL3A1, COL5A2, PDPN | MXRA5, FN1, COL5A2, CD44, TIMP2, COL1A1, BGN, SRGN, PARVA, ITGB2, DPYSL3, MMP2, LAMP2, DST, SPARC, WDR1, TLN1, PDLIM5, PSAP, SERPINF1, MIR21/TMEM49, CAPNS1, ANXA7, ACTG1, EXOC4, SH3PXD2A, DYNLL2, ABHD2, ACTB | JPH1 |
| Metabolism | FTL | SOD2, NNMT, GLUL, ALDH2, FTH1, PIGY, B4GALT1, FTL, APOE, CYBRD1, SERINC1, RNASEK, CSGALNACT2, GLRX, PPP1CA, GPX4, GPD2, GALC, CYB5R3, TATDN2 | ATAD3B, FXN, AGPAT5 |
| Degradation, protein folding, sorting, transport, trafficking | CTSB, ZFAND5 | SLC1A3, RAB31, ZFAND5, CALU, USP36, UBE2L6, ATP6V0E1, ARNT, RAB35, SEC23B, DNAJC3, SERINC3, PICALM, STX4, VPS53, AP2S1 | FKBP6, KCNK1, FBXO38, CACYBP |
| Differentiation | AHNAK, SLFN5 | ||
| Unknown function | AKIRIN1 | LOC100288387, LOC100129500, AKIRIN1, MARVELD1, TMEM140 | C3orf53, C6orf58, CXorf61, LOC100129069, C18orf18, PDZK1P1, LOC440957, RNFT2 |
The order of genes is based on fold-changes.
DLBCL, diffuse large B-cell lymphoma; FDR, false discovery rate; GCB, germinal center B-cell–like; p-AKThigh, high levels (≥70%) of phospho-AKT expression; p-AKTlow, low levels (<70%) of phospho-AKT expression.