Figure 5.

Pericyte (PC) protein remodeling facilitates neutrophil chemotaxis. A: Neutrophil chemotaxis along an IL-8 gradient through decellularized PC protein after 5 days of treatment in culture. B: Variable importance in projection (VIP) rankings from partial least squares analysis. Values above 1 are considered to influence the model. Error bars denote the 95% CI; dashed line, a VIP value of 1. C: Loading's plot resulting from partial least squares analysis of PC remodeling data and neutrophil chemotaxis results (R²Y = 0.66; Q² = 0.58). Data are expressed as means ± SEM (A and B). n = 4 (A). ^∗∗P < 0.01.