Table 3.

Multivariate Cox proportional hazards regression analysis

	Overall survival
	Univariate		Multivariate
Variables	RR (95% CI)	P value	RR (95% CI)	P value
Primary location	0.603 (0.407–0.893)	0.012	0.569 (0.377–0.858)	0.007
T stage	1.384 (0.190–10.062)	0.748
LVI	1.182 (0.819–1.708)	0.372
PNI	1.456 (0.722–2.937)	0.293
N stage	1.123 (0.267–4.717)	1.123
Regional LNs	0.981 (0.948–1.016)	0.281
Metastasis LNs	1.055 (1.006–1.106)	0.207
Sex	1.260 (0.873–1.817)	0.217
Diameter of LM	1.766 (1.233–2.530)	0.002	2.622 (1.618–4.248)	0.001
Neo-chemo	1.122 (0.654–1.925)	0.676
Histological type	1.733 (1.273–2.357)	0.001	0.194 (0.075–0.501)	0.001
CA199	1.727 (1.209–2.466)	0.003
Number of LM	2.330 (1.279–4.246)	0.006	2.134 (1.420–3.205)	0.001
CEA	1.926 (1.309–2.834)	0.001	1.624 (1.054–2.503)	0.028
Systemic chemo	0.738 (0.458–1.190)	0.213	0.582 (0.350–0.968)	0.037
Palliative resection	1.542 (1.065–2.232)	0.022	1.034 (0.973–1.098)	0.285

RR risk ratio, CI confidence interval, LVI lymphovascular invasion, PNI perineural invasion, LNs lymph nodes, LM liver metastasis, Neo-chemo neoadjuvant chemotherapy, Chemo chemotherapy, CEA carcinoembryonic antigen, CA cancer antigen