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. 2017 Jul 27;8:173. doi: 10.1186/s13287-017-0613-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Established mice model with different degrees of POA. a Numbers of four stages of follicles (primordial, primary, secondary, and antral follicles) counted from 0 to 4 weeks after different doses of CTX treatment. b Weight of the ovary measured after different doses of CTX treatment. c Serum hormone levels of E2, AMH, and FSH measured by ELISA after different doses of CTX treatment. d Litter size from the mice model with different degrees of POA. All experiments were carried out three times. Error bars indicate SD. *p < 0.05, ***p < 0.001, compared to control group; #p < 0.05, ##p < 0.01, compared with light-dose group