Fig. 2.

hAMSCs improved the function of the ovary more forcefully than hAECs. a Grafted (a) hAMSCs and (b) hAECs detected in vivo separately. Sterilized mice after tail-vein cell transplantation detected by live imaging for the identification of Dil-labeled cells in vivo. b Number of four-period follicles counted during 4 weeks after (a–d) hAMSC and (e–h) hAEC transplantation respectively. c Levels of E2, AMH, and FSH measured by ELISA at week 4 after hAMSC and hAEC transplantation respectively. d In the high-dose group, the weight of the ovary after hAEC transplantation was significantly lower than after hAMSC transplantation in the fourth week. All experiments were carried out three times. Error bars indicate SD. *p < 0.05, **p < 0.01,***p < 0.001, compared with medium-dose group; #p < 0.05, ##p < 0.01, compared with light-dose group. hAEC human amniotic epithelial cell, hAMSC human amniotic mesenchymal stem cell