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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Nat Commun. 2015 Apr 8;6:6749. doi: 10.1038/ncomms7749

Figure 8. NIPBL-mediated loading of the cohesin complex is required for the cardiogenic effect of OCT4.

Figure 8

NIBPL was downregulated by a siRNA. Cardiogenesis was monitored by the gene expression of cardiac-enriched genes (a) and (b) by immunostaining of cardiac transcription factors Nkx2.5 and Isl1 and a sarcomeric protein (actinin) in day 12 EBs. Scale bar indicates 50 µm. (c) Ectodermal and endodermal genes were monitored. Data are representative of three experiments (mean ± s.e.m., *Student’s t-test, P≤0.01).