Figure 6. Dynamic effector memory CD4 ⁺ T cell responses to norovirus infection.

The percentage change in frequency of CD4 ⁺ cmTeffs ( A), CD4 ⁺ emTeffs ( B) of total CD4 ⁺ T cells from baseline levels. The percentage change in frequency of CD69 ⁺ CD4 ⁺ cmTeffs ( C), CD69 ⁺ CD4 ⁺ emTeffs ( D), Ki-67 ⁺ CD4 ⁺ cmTeffs ( E) and Ki-67 ⁺ CD4 ⁺ emTeffs ( F) relative to their respective baseline levels in uninfected participants (filled green square+/-SEM) and the norovirus-infected participant (filled black circles). The shaded area indicates the period of reported gastroenteritis. Contour plots showing expression of CD69 and CD25 ( D) and Ki-67 and CD25 ( F) on CD4 ⁺ emTeffs pre-IL-2 administration (day 0) and at the peak of the response in the norovirus-infected participant (day 2 or 7 respectively).