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. 2017 Oct 5;2:28. Originally published 2017 Apr 18. [Version 3] doi: 10.12688/wellcomeopenres.11300.3

Figure 9. A counter-regulatory response to norovirus infection is coincident with effector cell mobilisation.

Figure 9.

The percentage change in frequency of mTregs ( A), CXCR3 + mTregs ( B) and CCR6 + mTregs ( C) of total CD4 + T cells in the norovirus-infected and uninfected participants. Phosphorylation of STAT5a (MFI) in mTregs in the norovirus-infected participant and controls (filled squares +/- SD) ( D). The percentage change in CD25 ( E), FOXP3 ( F) and CTLA-4 ( G) expression (MFI) relative to baseline on mTregs in controls or the norovirus-infected participant. Data were normalised to and expressed as percentage change from baseline (day 0) and measured in uninfected participants (filled green squares +/-SEM, n=5 apart from 9B and 9C where n=3) and the norovirus-infected (filled black circles) participant. The shaded area indicates the period of reported gastroenteritis. Histograms show the differential expression of CD25 ( E), Foxp3 ( F) and CTLA-4 ( G) at the peak of the response (day 3: CD25, FOXP3 and day 2: CTLA-4, blue line) versus day 0 pre-IL-2 (red line) and the shaded grey histogram is expression of CD25, CTLA-4 and FOXP3 in naïve CD4 + Teffs at day 0 in the norovirus-infected participant, as a negative control for staining.