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. 2016 Feb 8;66(5):930–938. doi: 10.1136/gutjnl-2015-310344

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x1/2pal-i1 treatment normalises liver–body weight ratio and prevents from hepatic necrosis. (A) Prophylactic and therapeutic x1/2pal-i1 administration result in a normal liver–body weight ration. Statistical analysis: Mann–Whitney U after Kruskal–Wallis. n=15 per group (n=7 for scram-i1 experiment). (B and C) Prophylactic and therapeutic x1/2pal-i1 treatment prevents from liver cell necrosis. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as markers of liver cell necrosis. Statistical analysis: Mann–Whitney U after Kruskal–Wallis. n=15 per group (n=7 for scram-i1 experiment).