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. 2016 Feb 8;66(5):930–938. doi: 10.1136/gutjnl-2015-310344

Figure 5.

Figure 5

(A) CXCR1/2 pepducin blockade reverses steatosis in alcoholic mice. Oil-red-O stain of liver sections of mice treated therapeutically. N=15. (B) Blockade of CXCR2 receptors decreases the triglyceride content in livers. Triglycerides from liver tissue of mice treated therapeutically were measured by a photometric assay. N=10. Statistical analysis: Mann–Whitney U test after Kruskal–Wallis. (C–E) The x1/2pal-i1 pepducin has no effect in mice on regular chow diet. Mice received the animal facility's standard chow diet. The animals were injected with either 10% of dimethyl sulfoxide or the x1/2pal-i1 pepducin (5 mg/kg) subcutaneous every other day. After 5 weeks of treatment, the animals were sacrificed and evaluated for (C) liver–body weight ratio, (D) alanine aminotransferase (ALT) and (E) aspartate aminotransferase (AST). N=10. Statistical analysis: Mann–Whitney U after Kruskal–Wallis; n.s.: p>0.05. LDC, Lieber–DeCarli diet.