Table 1.

Systemic metabolic and inflammatory parameters in fasted mice over the time course of the treatment

	NC			NC-Co			HFD			HFD-Co
Parameters	1 month	2 months	3 months	1 month	2 months	3 months	1 month	2 months	3 months	1 month	2 months	3 months
Insulinemia, pg/mL	465±17	440±11	483±32	472±18	462±33	518±18	636±36§	736±57§	784±109§	671±41#	732±62#	836±105#*
Leptinemia, pg/mL	741±505	683±376	760±385	940±263§	626±503	384±153	1626±589§	2023±451§	2347±254§	2209±63#*	1177±418#*	3474±421#*
IgG, µg/mL	1411±82	1199±73	2836±857	1468±91	1360±388	2231±561	1690±522	3199±1230§	5933±947§	991±98#*	2211±384#*	2362±514*
IFN-γ, pg/mL	36±25	230±106	255±420	13±8§	7±5§	14±7§	55±45	176±80	70±30	4±2*	7±3*	23±30*
IL-6, pg/mL	4±1	8±2	9±4	19±8§	21±10§	8±5	2±1	4±1	2±1	16±6*	18±5*	22±4*
IP10, pg/mL	73±17	108±17	138±25	100±33	87±13	95±10	81±18	93±12	100±19	96±15	110±18	126±7
RANTES, pg/mL	22±7	26±10	22±8	16±1	13±4	9±2	14±5	21±4	15±3	17±4	21±4	15±3
MIG, pg/mL	22±6	28±5	46±22	24±4	23±5	33±12	25±11	32±9	30±8	20±3	30±9	27±8
Antibodies Anti-P. gingivalis (EI)	1.45±0.24	1.54±0.24	1.49±0.14	3.89±2.44§	3.76±2.63§	3.58±1.82§	1.19±0.11	1.12±0.25	1.92±1.70	1.79±0.45#	1.17±0.27#	1.31±0.29#

N=6 per group; data as mean±SEM.

One-way ANOVA followed by Tukey's test used for *p<0.05 when compared to HFD, §p<0.05 when compared to NC and #p<0.05 when compared to NC-Co.

HFD, high-fat diet (n=6); HFD-Co, high-fat diet colonised (n=6) in the table; IFN, interferon; IL, interleukin; NC, normal chow (n=6); NC-Co, normal chow colonised (n=6).