Table 2.
Analysis of differences in hepatic BPA glucuronidation activities associated with liver donor demographics and UGT genotypes.
| BPA glucuronidation rate (nmoles/min/mg protein) |
|||||
|---|---|---|---|---|---|
| Variable | Group | n | Median | Interquartile range | P value |
| Gender | Male | 35 | 2.4 | 1.2 – 3.8 | 0.11a |
| Female | 11 | 1.8 | 0.6 – 3.1 | ||
| Drinks (per week) | <14 | 27 | 1.8 | 0.8 – 3.6 | 0.46a |
| 14 or more | 12 | 2.3 | 1.7 – 2.8 | ||
| Smoking | Yes | 15 | 2.0 | 1.1 – 3.1 | 0.70a |
| No | 25 | 2.3 | 1.0 – 3.7 | ||
| UGT1A1*28 | *1/*1 | 21 | 2.6 | 1.5 – 4.0 | 0.51b |
| *1/*28 | 13 | 1.6 | 0.9 – 3.5 | ||
| *28/*28 | 6 | 2.4 | 1.2 – 3.5 | ||
| UGT1A9*22 | *1/*1 | 16 | 2.4 | 1.2 – 3.5 | 0.012b |
| *1/*22 | 18 | 1.7 | 1.0 – 2.8 | ||
| *22/*22 | 6 | 4.4 | 3.2 – 4.8 | ||
| UGT2B15*2 | *1/*1 | 8 | 3.1 | 2.4 – 5.2 | 0.23b |
| *1/*2 | 25 | 1.8 | 0.9 – 3.4 | ||
| *2/*2 | 13 | 2.0 | 1.2 – 3.0 | ||
Rank sum test
Kruskal-Wallis one way analysis of variance on ranks.